Application : Functional ASL , Pharma Perfusion MRI & Reactivity Measurements

1. Introduction An important feature of brain perfusion is that it can adjust itself based on tissue demand and others conditions. This property is to some extent more clinically relevant compared to baseline perfusion only, because deficits in many brain disorders are often most pronounced when the brain is asked to perform a demanding task. Therefore, perfusion techniques are sometimes used in a dynamic manner in which brain perfusion is measured under two or more different physiologic conditions, from which the capacity of blood supply regulation is evaluated. In this lecture, applications related to dynamic measurement of perfusion are discussed.